This is the hub for every weight loss treatment comparison we publish. Each page below ranks real telehealth providers on the things that decide what you actually pay: the true monthly price, whether that price rises as your dose increases, what the first month costs after promos expire, and how easy it is to cancel.
Online GLP-1 programs now range from roughly $89 per month for entry-level compounded semaglutide to $399 or more for tirzepatide at higher doses. That gap is enormous — over a year, choosing the wrong program can cost you an extra $2,000 or more for the same active ingredient. Price is not the only thing that matters, but it is the thing providers hide best, so it is where our research starts.
Every ranking follows the same process, documented on our How We Rank page. In short: we research each provider's published pricing, dose policies, pharmacy sourcing, state coverage, and cancellation terms, then score them on a 10-point scale. We earn commissions from some partners, and we disclose that on every page. Scores are editorial assessments based on published information — we do not accept payment for a higher score, and we do not claim to have taken these medications ourselves.
A note on safety before you compare: most low-cost programs use compounded semaglutide or tirzepatide. Compounded medications are legal when prepared by licensed pharmacies, but they are not FDA-approved products, and quality depends on the pharmacy that makes them. If a deal looks too cheap to be real, check which pharmacy stands behind it — our reviews note this wherever the provider discloses it. And no ranking replaces a conversation with your own doctor about whether GLP-1 treatment is appropriate for you.
Start with the flagship comparison of the best weight loss injections if you want the full market view. If budget is the deciding factor, go straight to the cheapest online GLP-1 providers. If you already know which medication you want, the compounded semaglutide and tirzepatide pages compare providers for that specific drug. Uninsured? The GLP-1 without insurance guide covers every cash-pay route we know of, including the ones we would skip.